Simulation of inference test performance for minimum inhibitory concentration censored data

The estimation of the minimum inhibitory concentration is usually performed by a method of serial dilutions by a factor of 2, introducing the overestimation of antimicrobial efficacy, quantified by a simulation model that shows that the variability of the bias is higher for the standard deviation, b...

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Bibliographic Details
Published in:Journal of physics. Conference series 2022-01, Vol.2153 (1), p.12013
Main Authors: Torres-Mantilla, H A, Cuesta-Herrera, L, Andrades-Grassi, J E, Bianchi, G
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Data analysis
Decision analysis
Decision making
Error analysis
Inference
Physics
Simulation
Statistical analysis
Statistical methods
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Summary:The estimation of the minimum inhibitory concentration is usually performed by a method of serial dilutions by a factor of 2, introducing the overestimation of antimicrobial efficacy, quantified by a simulation model that shows that the variability of the bias is higher for the standard deviation, being dependent on the metric distance to the values of the concentrations used. We use a methodological approach through modeling and simulation for the measurement error of physical variables with censored information, proposing a new inference method based on the calculation of the exact probability for the set of possible samples from n measurements that allows quantifying the p -value in one or two independent sample tests for the comparison of censored data means. Tests based on exact probability methods offer a reasonable solution for small sample sizes, with statistical power varying according to the hypothesis evaluated, providing insight into the limitations of censored data analysis and providing a tool for decision making in the diagnosis of antimicrobial efficacy.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/2153/1/012013