The ambiguous role of sirtuins in head and neck squamous cell carcinoma

Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to regulate a variety of molecular signaling associated with different cancer types including oral malignancies. SIRT1...

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Bibliographic Details
Published in:Oral diseases 2022-04, Vol.28 (3), p.559-567
Main Authors: Ezhilarasan, Devaraj, Lakshmi, Thangavelu, Subha, Manoharan, Deepak Nallasamy, Veeraiyan, Raghunandhakumar, Subramanian
Format: Article
Language:English
Subjects:
Cell migration
Cell Proliferation
Head & neck cancer
Head and neck carcinoma
Head and Neck Neoplasms
histone deacetylases
Histones
Humans
Invasiveness
Morbidity
Mouth Neoplasms
Oral cancer
Oral carcinoma
oral squamous cell carcinoma
SIRT1 protein
Sirtuins
Sirtuins - metabolism
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck
Tumor suppressor genes
Tumors
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Summary:Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to regulate a variety of molecular signaling associated with different cancer types including oral malignancies. SIRT1 acts as bifunctional in a variety of cancer. In oral cancer, SIRT1 seems to work as a tumor suppressor. The carcinogenic potential of SIRT1 is also reported in oral cancer, and hence, its role is still ambiguous. SIRT2 is also said to play a dual‐faced role in different types of cancers. However, in oral cancer, SIRT2 is not studied and its role remains obscure. SIRT3 expression was positively correlated with oral malignancies. However, studies also showed the anti‐cancer role of SIRT3 in oral cancer. SIRT7 loss was observed in oral cancer cells, while its overexpression caused the suppression of oral cancer cells proliferation, migration, and invasiveness. The role of other SIRTs in oral cancer was studied meagerly or reports not available. To date, only the roles of SIRT1, SIRT3, and SIRT7 have been reported in oral malignancies. Therefore, understanding the regulatory mechanisms employed by sirtuins to modulate oral cancer is important for developing potential anti‐cancer therapeutic strategies.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13798