Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma

Study design Retrospective cohort study. Objectives Although intramedullary astrocytoma is associated with a high mortality rate, the optimal treatment has not reached a consensus. This study aimed at evaluating neurologic function and overall survival rate (OSR) in the treatment of this tumor. Sett...

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Bibliographic Details
Published in:Spinal cord 2022-03, Vol.60 (3), p.216-222
Main Authors: Nagoshi, Narihito, Tsuji, Osahiko, Suzuki, Satoshi, Nori, Satoshi, Yagi, Mitsuru, Okada, Eijiro, Okita, Hajime, Fujita, Nobuyuki, Ishii, Ken, Matsumoto, Morio, Nakamura, Masaya, Watanabe, Kota
Format: Article
Language:English
Subjects:
692/617/375/1922
692/699/375/1824
Anatomy
Astrocytoma
Astrocytoma - diagnostic imaging
Astrocytoma - surgery
Biomedical and Life Sciences
Biomedicine
Chemotherapy
Clinical outcomes
Evaluation
Human Physiology
Humans
Neurochemistry
Neuropsychology
Neurosciences
Neurosurgical Procedures - methods
Radiation
Radiation therapy
Retrospective Studies
Spinal cord
Spinal Cord Injuries - surgery
Spinal Cord Neoplasms - diagnostic imaging
Spinal Cord Neoplasms - surgery
Survival
Thorax
Treatment Outcome
Tumors
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Summary:Study design Retrospective cohort study. Objectives Although intramedullary astrocytoma is associated with a high mortality rate, the optimal treatment has not reached a consensus. This study aimed at evaluating neurologic function and overall survival rate (OSR) in the treatment of this tumor. Setting The single institution in Japan. Methods This study enrolled 67 subjects who underwent surgical treatment for intramedullary astrocytoma. Demographic, imaging, and surgical information were collected from each participant. Tumors were histologically categorized using the World Health Organization classification, and subjects were divided into low-grade (I and II; n  = 40) and high-grade (III and IV; n  = 27) groups. Neurologic status was evaluated using the modified McCormick scale (MMS). OSR was assessed using Kaplan–Meier methods. Results The OSR decreased when the pathological grade increased ( p  
ISSN:1362-4393
1476-5624
DOI:10.1038/s41393-021-00676-8