Bioflavonoid mediated synthesis of TiO2 nanoparticles: Characterization and their biomedical applications

[Display omitted] •TiO2 nanoparticles were synthesized by green method using a bioflavonoid, rutin.•The method was eco-friedly, simple, cost-effective and non-toxic.•FT-IR, XRD, SEM and TEM studies aided to analyse structure of synthesized TiO2NPs.•Biosynthesized TiO2NPs showed promising in-vitro bi...

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Published in:Materials letters 2022-03, Vol.311, p.131639, Article 131639
Main Authors: Dessai, Sharvari, Ayyanar, Muniappan, Amalraj, Singamoorthy, Khanal, Pukar, Vijayakumar, Subramaniyan, Gurav, Nilambari, Rarokar, Nilesh, Kalaskar, Mohan, Nadaf, Sameer, Gurav, Shailendra
Format: Article
Language:English
Subjects:
Anatase
Antioxidants
Biocompatibility
Bioflavonoid
Biomedical materials
Biosynthesis
Diffraction
Free radicals
Glucosidase
Materials science
Nanoparticles
Rutin
Scavenging
Synthesis
Titanium dioxide
Toxicity
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Summary:[Display omitted] •TiO2 nanoparticles were synthesized by green method using a bioflavonoid, rutin.•The method was eco-friedly, simple, cost-effective and non-toxic.•FT-IR, XRD, SEM and TEM studies aided to analyse structure of synthesized TiO2NPs.•Biosynthesized TiO2NPs showed promising in-vitro biological properties.•TiO2NPs synthesized using rutin could be employed in pharmaceutical applications. The present study dealt with the rutin mediated synthesis of titanium dioxide nanoparticles (TiO2NPs), their characterization, and evaluation of antibacterial, antidiabetic, and antioxidant properties. XRD spectrum of uncalcined TiO2NPs did not show any distinct diffraction peaks revealing its amorphous nature, while calcinated TiO2NPs showed prominent diffraction peaks indicating its crystalline anatase form. SEM and TEM images helped to understand uniform spherical structure of synthesized uncalcined TiO2NPs, whereas EDX analysis exhibited unique mineral content. Rutin, uncalcined, and calcinated TiO2NPs showed good free radical scavenging, moderate α-amylase, and α-glucosidase inhibitory activities. Overall, biosynthesized TiO2NPs showed promising antibacterial, antidiabetic, and antioxidant properties with no observed toxicity. Furthermore, these biosynthesized nanoparticles are equally compatible with nanoparticles prepared via chemical methods.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2021.131639