GATE/GEANT4 simulation of radiation risk induced cancer from mammographic screening

• Published in: Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2022-04, Vol.193, p.109929, Article 109929
• Main Authors: Fathi, I., Mkimel, M., El baydaoui, R., El rhazouani, O., Mesradi, M.R.
• Format: Article
• Language: English
• Subjects: Cancer; Dosimeters; Effective risk; EVA; FASH 3; GATE; Mathematical analysis; Monte Carlo simulation; Organs; Radiation; Radiation effects; Risk; Screening; Simulation
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2021.109929

The main objective of the paper is to estimate organ risk of radiation-induced cancer using Monte Carlo simulation Gate/Geant4 applying the Moroccan breast screening guidelines using digital mammography (DM) technique taken into consideration two views (cranio-caudal (CC) and medio-lateral oblique (MLO)), considering the age range of 45–60 years. We apply a new approach consisting of the use of a female voxel phantom EVA and FASH 3 computational phantoms merged with three-layer heterogeneous mammographic phantoms to estimate the incidence risks of cancer on a particular organ and the calculation of the total effective risk of radiation-induced cancer. The effective risk (ER) discrepancy between standing posture phantom FASH 3 and supine posture EVA phantom for organs were: 29.9% (breast examined), 54.83% (thyroid), and 10.97% (total effective risk). These results show a posture sensitivity in terms of organ dose calculation. To investigate the impact of glandular distribution on the ER, each layer of the breast was set to a glandular fraction of 25%, 50%, or 75% to simulate a glandular heterogeneous distribution of uniform, concentrated, superior, and inferior glandular distributions. The heterogeneous distribution shows lower values of the total effective risk of radiation-induced cancer of those of uniform one. This finding shows that the total effective risk for radiation-induced cancer using voxel phantom and heterogeneous breast distribution should be considered in clinical practice to provide DRL in conventional breast dosimetry. •Estimation of risk of radiation-induced injury for digital breast mammography.•Organ dose for FASH 3 and Eva phantom present a difference above 60%.•Contralateral breast and lung were estimated to have a considerable effective risk.•Effective risk is about 25.5% lower when a heterogeneous breast is considered.