Role of structural properties of bioactive peptides in their stability during simulated gastrointestinal digestion: A systematic review

The biological activities of food-derived bioactive peptides (BAPs) depend on their specific structural properties. BAP structures may be altered in the gastrointestinal tract, resulting in poor in vivo translatability of in vitro bioactivity. Structure-biostability relationship of BAPs is not well...

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Bibliographic Details
Published in:Trends in food science & technology 2022-02, Vol.120, p.265-273
Main Authors: Ahmed, Tausif, Sun, Xiaohong, Udenigwe, Chibuike C.
Format: Article
Language:English
Subjects:
Amino acids
Bioactive peptides
Biocompatibility
Biological activity
Biostability
Chain branching
Digestion
Digestive system
Gastrointestinal digestion
Gastrointestinal system
Gastrointestinal tract
Guidelines
High performance liquid chromatography
Histidine
Hydrophobicity
Intestine
Leucine
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Peptides
Proline
Residues
Reviews
Simulation
Structural properties
Structure-stability relationship
Systematic review
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Summary:The biological activities of food-derived bioactive peptides (BAPs) depend on their specific structural properties. BAP structures may be altered in the gastrointestinal tract, resulting in poor in vivo translatability of in vitro bioactivity. Structure-biostability relationship of BAPs is not well understood. Thus, this systematic review investigated all eligible studies reporting peptide sequences during in vitro digestion to determine structural properties associated with biostability. Using PRISMA guidelines, a systematic search was performed in MEDLINE and SCOPUS from the date of inception to August 2020 for studies (1) investigating isolated peptides with
ISSN:0924-2244
1879-3053
DOI:10.1016/j.tifs.2022.01.008