In-Vitro Evaluation of Some Traditional Medicinal Plants on Calcium Oxalate Urolithiasis

The prevalence of urolithiasis in Middle East countries is predominantly high. Traditional medicinal plants play a role in the prevention and management of urolithiasis. The effect of Petroselinum crispum, rind of Citrus sinensis L., rind of Citrus limon L., Ammi visnaga (L.) LAM., Tamarindus indica...

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Bibliographic Details
Published in:Emirates journal of food and agriculture 2021-12, Vol.33 (12), p.1018-1027
Main Authors: . Abdel Bar, Fatma, Foudah, Ahmed, Majrashi, Amjad, Dossery, F. Al, Galala, Amal
Format: Article
Language:English
Subjects:
Calcium
Calcium oxalate
Citrus fruits
Crystallization
Crystals
Herbal medicine
Hibiscus sabdariffa
Ileum
Kidney stones
Lithiasis
Lithotripsy
Medicinal plants
Muscle relaxants
Natural products
Nigella sativa
Oxalic acid
Parasympathetic nervous system
Pharmacy
Plants
Potassium
Roselle
Seeds
Small intestine
Smooth muscle
Sodium
Urinary tract diseases
Urine
Urolithiasis
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Summary:The prevalence of urolithiasis in Middle East countries is predominantly high. Traditional medicinal plants play a role in the prevention and management of urolithiasis. The effect of Petroselinum crispum, rind of Citrus sinensis L., rind of Citrus limon L., Ammi visnaga (L.) LAM., Tamarindus indica L., Nigella sativa L., Cymbopogon proximus Hochst. ex A. Rich., Hibiscus sabdariffa L., Hordeum vulgare L., and Cymbopogon schoenanthus (L.) Spreng. on calcium oxalate crystallization was investigated in-vitro. The antispasmodic activity on acetylcholine-induced contraction in rat ileum was also screened ex-vivo.  A significant reduction in the mean diagonal of calcium oxalate crystals was observed for P. crispum, C. proximus, N. sativa, and C. limon (4.41 mm, 4.71, 5.44, and 5.67 mm, respectively) compared to the negative control (12.19 mm). H. sabdariffa exhibited antinucleation effect however, P. crispum showed a marked inhibition of calcium oxalate aggregation at 10 mg/mL after 60 min compared to the negative control. A remarkable ex-vivo antispasmodic activity was observed for C. proximus, C. schoenanthus, and A. visnaga extracts. Our results provide scientific evidence for the traditional use of the studied plant-derived products as potential therapies for calcium oxalate urolithiasis.
ISSN:2079-052X
2079-0538
DOI:10.9755/ejfa.2021.v33.i12.2792