Palladium‐Catalyzed Alkynylation of Alkenes via C−H Activation for the Preparation of Conjugated 1,3‐Enynes

A general palladium‐catalyzed method for the direct alkynylation of unactivated alkenes via C−H activation, was successfully developed, with the assistance of 8‐aminoquinoline. It is applicable to both internal and terminal unactivated alkenes with a broad functionality tolerance. This method shows...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-03, Vol.364 (6), p.1109-1116
Main Authors: Guo, Li‐Yun, Li, Qing, Liu, Yu‐Tao, Li, Lin, Ni, Yu‐Qing, Li, Yang, Pan, Fei
Format: Article
Language:English
Subjects:
Alkenes
Alkynylation
Aminoquinolines
C−H activation
Enynes
Palladium
Stereoselectivity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A general palladium‐catalyzed method for the direct alkynylation of unactivated alkenes via C−H activation, was successfully developed, with the assistance of 8‐aminoquinoline. It is applicable to both internal and terminal unactivated alkenes with a broad functionality tolerance. This method shows good regio‐ and diastereoselectivity and provides an alternative approach for directing construct of conjugated 1,3‐enynes.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202101365