Formulation and Evaluation of Chewable Tablets of Anti-Asthmatic Drug

Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are be...

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Published in:Research journal of pharmacy and technology 2022-01, Vol.15 (1), p.137-142
Main Authors: Suruse, P B, Band, K S, Ingole, A R, Baheti, J R
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Language:English
Subjects:
Asthma
Cellulose
Drug dosages
Sodium
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Ingole, A R
Baheti, J R
description Montelukastsodium is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. In addition, patients with asthma need fast and immediate action of drug and avoidance of water is also desirable. Further, chewable tablets are beneficial for patients having difficulty in swallowing. The objective of the present study was to develop chewable tablets containing different compositions of ingredients by using direct compression method. Microcrystalline cellulose, mannitol, magnesium stearate, cross povidone and aspartame were used in the formulation in different concentrations. The prepared tablets were evaluated for various parameters like weight variation, thickness, friability, drug content, and in-vitro drug release. The in-vitro release study of formulation F7 was found to show 98% drug release in 30 minutes and stability studies showed no significant changes.
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subjects Asthma
Cellulose
Drug dosages
Sodium
title Formulation and Evaluation of Chewable Tablets of Anti-Asthmatic Drug
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