DNA origami nanocalipers for pH sensing at the nanoscale

A DNA origami nanocaliper is employed as a shape-resolved nanomechanical device, with pH-responsive triplex DNA integrated into the two arms. The shape transition of the nanocaliper results in a subtle difference depending on the local pH that is visible via TEM imaging, demonstrating the potential...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-03, Vol.58 (22), p.3673-3676
Main Authors: Zhang, Xinyue, Pan, Li, Guo, Ruiyan, Zhang, Yueyue, Li, Fan, Li, Min, Li, Jiang, Shi, Jiye, Qu, Fengli, Zuo, Xiaolei, Mao, Xiuhai
Format: Article
Language:English
Subjects:
DNA
Hydrogen-Ion Concentration
Nanostructures
Nanotechnology - methods
Nucleic Acid Conformation
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Summary:A DNA origami nanocaliper is employed as a shape-resolved nanomechanical device, with pH-responsive triplex DNA integrated into the two arms. The shape transition of the nanocaliper results in a subtle difference depending on the local pH that is visible via TEM imaging, demonstrating the potential of these nanocalipers to act as a universal platform for pH sensing at the nanoscale. We report a shape-resolved nanomechanical device based on a DNA origami nanocaliper for pH sensing at the nanoscale.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06701j