Amorphous and crystalline cerium() phosphates: biocompatible ROS-scavenging sunscreens

This paper reports on a comprehensive study of the UV-shielding properties (namely, the sun protection factor and the factor of protection against UV-A radiation) and cytotoxicity (including photocytotoxicity) of amorphous and crystalline cerium( iv ) phosphates. It has been shown that cerium( iv )...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-03, Vol.1 (11), p.1775-1785
Main Authors: Kozlova, T. O, Popov, A. L, Kolesnik, I. V, Kolmanovich, D. D, Baranchikov, A. E, Shcherbakov, A. B, Ivanov, V. K
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Cerium
Cerium - chemistry
Cerium - pharmacology
Cerium oxides
Crystal structure
Crystallinity
Cytotoxicity
Fibroblasts
Lanthanide phosphates
Mesenchyme
Mice
Nanocrystals
Phosphates
Radiation shielding
Reactive Oxygen Species
Scavenging
Stem cell transplantation
Stem cells
Sun screens
Sunscreening Agents - pharmacology
Sunscreens
Titanium dioxide
Toxicity
Ultraviolet radiation
Ultraviolet Rays
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Summary:This paper reports on a comprehensive study of the UV-shielding properties (namely, the sun protection factor and the factor of protection against UV-A radiation) and cytotoxicity (including photocytotoxicity) of amorphous and crystalline cerium( iv ) phosphates. It has been shown that cerium( iv ) phosphate NH 4 Ce 2 (PO 4 ) 3 is characterised by UV-shielding properties that are comparable to those of nanocrystalline TiO 2 and CeO 2 . Moreover, cerium( iv ) phosphates did not show toxicity towards cell cultures of NCTC L929 line mouse fibroblasts and human mesenchymal stem cells, in a wide range of concentrations, and even enhanced the proliferative activity of the latter. In a model study of the photoprotective properties of cerium( iv ) phosphates on human mesenchymal stem cells, the pronounced protective effect of NH 4 Ce 2 (PO 4 ) 3 was observed, which was comparable to the shielding action of nanocrystalline CeO 2 . The results have shown that tetravalent cerium phosphates can be considered as promising UV-filters for sunscreen applications. This paper reports on the good UV-shielding properties (namely, the sun protection factor and the factor of protection against UV-A radiation) and low cytotoxicity (including photocytotoxicity) of amorphous and crystalline cerium( iv ) phosphates.
ISSN:2050-750X
2050-7518
DOI:10.1039/d1tb02604f