Graft‐versus‐host disease‐associated angiomatosis with striking lipomatous metaplasia

Sclerodermatous graft‐versus‐host disease (GvHD) is one of the many clinicopathological variants of chronic GvHD. One of the rarest forms of this variant is GvHD‐associated angiomatosis (GvHD‐AA). We describe the case of a 62‐year‐old male with sclerodermatous GvHD who presented, in consecutive year...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2022-04, Vol.49 (4), p.373-376
Main Authors: Llamas‐Velasco, Mar, Muñoz‐Aceituno, Ester, Sánchez‐Pérez, Javier, Camarero‐Mulas, Celia, Fraga, Javier, Aragüés, Maximiliano
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Angiomatosis
Angiomatosis - pathology
Atrophy
Body fat
Bone Marrow Transplantation - adverse effects
Graft vs Host Disease - pathology
Graft-versus-host reaction
graft‐versus‐host disease
Humans
Hypoxia
Inflammation
Lesions
Lipomatosis - pathology
lipomatous metaplasia
Male
Metaplasia
Metaplasia - pathology
Middle Aged
Nevus
Skin - pathology
stem cell
vascular tumor
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Summary:Sclerodermatous graft‐versus‐host disease (GvHD) is one of the many clinicopathological variants of chronic GvHD. One of the rarest forms of this variant is GvHD‐associated angiomatosis (GvHD‐AA). We describe the case of a 62‐year‐old male with sclerodermatous GvHD who presented, in consecutive years, two different lesions that showed characteristics of GvHD‐AA. The first lesion fitted perfectly with the previously known features of this rare entity. However, the second lesion was more interesting, as the angiomatoid lesion was surrounded by newly appeared adipocytes, something not previously described. The appearance of this peculiar adipose tissue may be explained as related to an important dermal atrophy, as a concomitant appearance of a lipomatous nevus and GvHD‐AA, or, finally, as mature adipose tissue related to a previous inflammatory process, that is, lipomatous metaplasia. Both lesions were diagnosed as GvHD‐AA, and the second one was considered to be associated with dermal lipomatous metaplasia. We also considered whether hypoxia could be related to both lesions. In the present report, we review previously published cases of GvHD‐AA and discuss the different hypotheses that could explain the appearance of metaplasia associated with the second lesion.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14162