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Primary cutaneous follicle center lymphoma with aberrant CD8 expression

We report an unusual case of primary cutaneous follicle center lymphoma (PCFCL) with aberrant expression of the T‐cell marker CD8. The patient is a 48‐year‐old male with no significant past medical history who presented with red indurated plaques on the abdomen. A punch biopsy showed abnormal lympho...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2022-04, Vol.49 (4), p.403-407
Main Authors: Lee, Jack, Cohen, Jason A., Wrone, David A., Gru, Alejandro A.
Format: Article
Language:English
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Summary:We report an unusual case of primary cutaneous follicle center lymphoma (PCFCL) with aberrant expression of the T‐cell marker CD8. The patient is a 48‐year‐old male with no significant past medical history who presented with red indurated plaques on the abdomen. A punch biopsy showed abnormal lymphoid follicles in the dermis with reduced mantle zones and decreased tingible body macrophages. The epidermis was uninvolved. The follicles expressed CD20, PAX‐5, and bcl‐6 by immunohistochemistry. CD8, however, was strongly positive, highlighting neoplastic cells, which were negative for any additional T‐cell markers. TIA and granzyme B were also negative. The patient underwent further staging workup, without evidence of nodal involvement. His course has been indolent thus far. In summary, we present a case of PCFCL with aberrant expression of the T‐cell marker CD8, a finding not previously reported in the literature and a potential diagnostic pitfall.
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14173