Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (...

Full description

Saved in:
Bibliographic Details
Published in:Records of natural products 2021-11, Vol.15 (6), p.602-607
Main Authors: Çetinel Aksoy, Semiha, Küçüksolak, Melis, Uze, Ataç, Bedir, Erdal
Format: Article
Language:English
Subjects:
Benzodiazepines
Microorganisms
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.203.20.08.1766