Synthesis, characterization and investigation of photophysical and biological properties of Cu(II) and Zn(II) complexes of benzimidazole ligands

• Published in: Applied organometallic chemistry 2022-04, Vol.36 (4), p.n/a
• Main Authors: Sherwani, Ibrahim Ali Hamad Ameen, Köse, Ayşegül, Güngör, Özge, Kırpık, Hilal, Güngör, Seyit Ali, Köse, Muhammet
• Format: Article
• Language: English
• Subjects: Alkylation; benzimidazole; Binding; Biological properties; Chemistry; Coordination compounds; Crystals; Ligands; metal complex; Single crystals; Spectrophotometry; Synthesis; X‐ray diffraction and DNA binding
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.6585

In this work, two benzimidazole ligands (L1 and L2) containing a central pyridine ring that have two alkylated (pentyl for L1 and hexyl for L2) benzimidazole units at the second and sixth positions were synthesized. Mononuclear Cu(II) and Zn(II) complexes with the general formulae of [ML(X)2] (where M: Cu(II) or Zn(II), L: L1 or L2 and X: NO3− or NCS−) were synthesized, and their structures were characterized by the spectroscopic and analytical methods. Moreover, Cu(II) complexes [CuL1(Bipy)](ClO4)2 and [CuL2(Bipy)](ClO4)2 (where Bipy: 2,2′‐bipyridine) were also prepared. The solid structures of complexes [CuL1(NCS)2, [CuL1(Bipy)](ClO4)2 and [CuL2(NO3)(EtOH)]NO3 were determined by single crystal X‐ray diffraction studies. The DNA binding properties of the ligands and their metal complexes were investigated by the spectrophotometric titrations. The compounds showed considerable DNA binding affinities. The structural variations and coordination geometry around the metal centre were found to affect the binding properties. Two N‐alkylated benzimidazole ligands and mononuclear Cu(II)/Zn(II) complexes were synthesized and characterized by the spectroscopic and analytical methods. The DNA binding properties of the ligands and their metal complexes were investigated by the spectrophotometric titrations. The compounds showed considerable DNA binding affinities, and their binding capabilities are comparable with those DNA binding agents.