Preparation of PVA/starch hydrogel and its in-vitro drug release potential against pus-inducing pathogenic strain and breast cancer cell line

The starch was blended with poly(vinyl) alcohol (PVA) to develop PVA/starch (PS) hydrogel. The physical interaction of PVA with starch was concluded by FTIR and XRD techniques. The thermal decomposition behavior of PS hydrogel was analyzed by thermogravimetric analysis. The swelling index and moistu...

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Bibliographic Details
Published in:Journal of sol-gel science and technology 2022-03, Vol.101 (3), p.571-578
Main Authors: Sankarganesh, P., Parthasarathy, V., Kumar, A. Ganesh, Ragu, S., Saraniya, M., Udayakumari, N.
Format: Article
Language:English
Subjects:
Anticancer properties
Biocompatibility
Breast cancer
Cephalosporins
Ceramics
Chemistry and Materials Science
Composites
Erythrocytes
Glass
Hydrogels
Inorganic Chemistry
Mannitol
Materials Science
Moisture effects
Nanotechnology
Natural Materials
Optical and Electronic Materials
Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
Polyvinyl alcohol
Thermal decomposition
Thermogravimetric analysis
Water absorption
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Summary:The starch was blended with poly(vinyl) alcohol (PVA) to develop PVA/starch (PS) hydrogel. The physical interaction of PVA with starch was concluded by FTIR and XRD techniques. The thermal decomposition behavior of PS hydrogel was analyzed by thermogravimetric analysis. The swelling index and moisture loss analysis was carried out to comprehend the water absorption and retention behavior of PS hydrogel. The PS hydrogel was biocompatible with RBC due to its lower hemolysis value. The curcumin-loaded PS hydrogel showed an excellent anticancer activity against breast cancer cell line. The antibacterial activity of cephalosporin-loaded PS hydrogel was evaluated against the Staphylococcus aureus . Graphical abstract Highlights The PVA/mannitol hydrogel was prepared to study its drug delivery potential. The PM hydrogel effectively delivered the drugs against MCF-7 and pathogenic strains. The PM hydrogel exhibited an excellent water retention ability. The prepared PM hydrogel was non-hemolytic to red blood cells.
ISSN:0928-0707
1573-4846
DOI:10.1007/s10971-022-05735-x