Ionic liquid functionalized injectable and conductive hyaluronic acid hydrogels for the efficient repair of diabetic wounds under electrical stimulation

The treatment and care of diabetic wounds remains a global challenge due to the high rates of amputation, recurrence, and mortality. It has been proven that electrical stimulation has a positive effect on promoting diabetic wound healing. Hyaluronic acid is an acidic mucopolysaccharide that exhibits...

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Published in:Biomaterials science 2022-03, Vol.1 (7), p.1795-182
Main Authors: Liu, Pan, Jin, Kai, Zong, Yuange, He, Meng, Lu, Chunfeng, Li, Huiyue, Wang, Yanying, Li, Chunya
Format: Article
Language:English
Subjects:
Antibiotics
Diabetes
Diabetes Mellitus
Electric Conductivity
Electric Stimulation
Electrical resistivity
Humans
Hyaluronic Acid
Hydrogels
Hydrogels - chemistry
Ionic Liquids
Mechanical properties
Stimulation
Substrates
Wound Healing
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Summary:The treatment and care of diabetic wounds remains a global challenge due to the high rates of amputation, recurrence, and mortality. It has been proven that electrical stimulation has a positive effect on promoting diabetic wound healing. Hyaluronic acid is an acidic mucopolysaccharide that exhibits important physiological functions in the body. However, it is not an ideal electrical substrate because of its poor electrical conductivity. In this work, a series of novel ionic liquid functionalized injectable and conductive hydrogels was prepared based on hyaluronic acid. The obtained hydrogels exhibited excellent electrical conductivity, flexibility and mechanical properties, and conferred significant antibacterial effects without the need for additional antibiotics. These hydrogels coupled with exogenous electrical stimulation can significantly accelerate diabetic wound healing compared with the commercial Tegaderm™ film. The treatment and care of diabetic wounds remains a global challenge due to the high rates of amputation, recurrence, and mortality.
ISSN:2047-4830
2047-4849
DOI:10.1039/d2bm00026a