Valproik Asit Uygulamasının Embriyo İmplantasyon Bölgesinde Vazoaktif İntestinal Peptid ve Siklooksijenaz-2 Aktivitesi Üzerine Etkisi

The aim of our study was to investigate the distribution of cyclooxygenase-2 (COX-2) and vasoactive intestinal peptide (VIP) molecules during embryo implantation in rats administered valproic acid (VPA). Method: 20 female rats were randomly divided into two groups, Group 1 was determined as Control,...

Full description

Saved in:
Bibliographic Details
Published in:Dicle tıp dergisi 2021-12, Vol.48 (4), p.865-873
Main Authors: Yazıcı, Gülce Naz, Gürgen, Seren Gülşen, Sunar, Mukadder, Cansu, Ali
Format: Article
Language:Turkish
Subjects:
Antibodies
Epilepsy
Peptides
Uterus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of our study was to investigate the distribution of cyclooxygenase-2 (COX-2) and vasoactive intestinal peptide (VIP) molecules during embryo implantation in rats administered valproic acid (VPA). Method: 20 female rats were randomly divided into two groups, Group 1 was determined as Control, Group 2 as VPA Group. 1. Subjects were mated with male rats in a controlled cages and manner; mating day was accepted as day 0 and on day 7, the subjects were sacrificed under high-dose anesthesia and the tissues of the uterine implantation site were removed. Conclusion: With the immunohistochemical evaluation and supporting statistical data in our study; Long-term use of VPA reduces the expression of COX-2 and VIP during pregnancy; It has been concluded that this decrease may adversely affect embryo implantation and thus the progression of pregnancy and pose a risk.
ISSN:1300-2945
1308-9889
DOI:10.5798/dicletip.1037848