A novel stimuli-responsive magnetic hydrogel based on nature-inspired tragacanth gum for chemo/hyperthermia treatment of cancerous cells

An efficient and facile strategy for the fabrication of a bioinspired drug delivery system (DDS) was designed and developed successfully based on tragacanth gum (TG) owing to its wide range of biological and pharmacological activities ( e.g., anti-tumor). For this objective, the reduced TG (TG-OH) w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of polymer research 2022-04, Vol.29 (4), Article 149
Main Authors: Khani, Ali, Eskandani, Morteza, Derakhshankhah, Hossein, Soleimani, Khadijeh, Nakhjavani, Sattar Akbari, Massoumi, Bakhshali, Jahanban-Esfahlan, Rana, Moloudi, Kave, Jaymand, Mehdi
Format: Article
Language:English
Subjects:
Anticancer properties
Biomimetics
Cationic polymerization
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Doxorubicin
Drug delivery systems
Drugs
Hydrogels
Hyperthermia
Industrial Chemistry/Chemical Engineering
Iron oxides
Nanoparticles
Original Paper
Polymer Sciences
Polymerization
Reduction
Ring opening polymerization
Tragacanth
Vehicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient and facile strategy for the fabrication of a bioinspired drug delivery system (DDS) was designed and developed successfully based on tragacanth gum (TG) owing to its wide range of biological and pharmacological activities ( e.g., anti-tumor). For this objective, the reduced TG (TG-OH) was tosylated (TG-OTs), and then 2-ethyl-2-oxazoline (EtOx) monomer was grafted onto purified TG through a cationic ring-opening polymerization (CROP) technique. The polymerization was terminated and simultaneously crosslinked by the addition of amine-modified Fe 3 O 4 nanoparticles and cystamine (Cys) moiety to afford a TG- g -PEtOx/Fe 3 O 4 as a pH- and reduction-sensitive magnetic hydrogel (MH). The fabricated MH exhibited excellent doxorubicin hydrochloride (Dox) encapsulation efficiency (83.1 ± 3.1) owing to its porous micro-structure and robust physical interactions between the drug molecule and polymeric network. In vitro drug release studies results confirmed the pH- and reduction-responsiveness of the developed MH/Dox system. The anticancer performance study by MTT-assay revealed that the developed MH/Dox has excellent potential for “smart” chemo/hyperthermia therapy of cancerous cells.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-022-03004-7