Giant cell tumor of hyoid bone: Diagnostic dilemma with a novel management

Giant cell tumor of bone (GCTB) is locally aggressive tumor occurring in the epiphysis of long bones. GCTBs are uncommon tumors in the head-and-neck region and rarely involve hyoid bone. We report a case of GCTB of hyoid bone. The patient presented with swelling in left submandibular region. The tum...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2022-01, Vol.18 (1), p.282-285
Main Authors: Bihani, Ameya, Thiagarajan, Shivakumar, Chaukar, Devendra, D'Cruz, Anil
Format: Article
Language:English
Subjects:
Bone cancer
Bone Density Conservation Agents
Bone Neoplasms - pathology
Bone tumors
Care and treatment
Case studies
Denosumab
Diagnosis
Giant Cell Tumor of Bone - diagnosis
Giant Cell Tumor of Bone - surgery
Giant cell tumors
Head and neck tumors
Humans
Hyoid Bone - metabolism
Hyoid Bone - pathology
Male
Monoclonal antibodies
Respiratory failure
Targeted cancer therapy
Tumors
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Description
Summary:Giant cell tumor of bone (GCTB) is locally aggressive tumor occurring in the epiphysis of long bones. GCTBs are uncommon tumors in the head-and-neck region and rarely involve hyoid bone. We report a case of GCTB of hyoid bone. The patient presented with swelling in left submandibular region. The tumor was surgically excised after initial denosumab therapy. Despite adequate resection and rehabilitation, he was tube dependent. Subsequently it was found that the patient had a coexisting myotonic dystrophy, unknown to exist with GCTB of hyoid. Eventually, the patient succumbed to respiratory failure secondary to myotonic dystrophy. GCTB hyoid is a rare presentation posing a diagnostic dilemma. Ours is the first case to report the use of denosumab for GCT in head-and-neck region. Myotonic dystrophy Type I and GCTB are both known to result from abnormality of closely situated foci on chromosome 19.
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.JCRT_205_19