Amphiphilic conjugated block copolymers as NIR-bioimaging probes

Although semiconducting polymer nanoparticles (SPN) are emerging as versatile theragnostic platforms for drug delivery and near infrared (NIR)-imaging, their synthesis remains restricted to nanoprecipatation or graft polymers. Here we present a novel method for creating an SPN of the donor-acceptor...

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Bibliographic Details
Published in:Polymer chemistry 2022-04, Vol.13 (14), p.257-264
Main Authors: Buckinx, Axel-Laurenz, Rozario, Ashley M, Bell, Toby D. M, Michels, Jasper J, Junkers, Tanja
Format: Article
Language:English
Subjects:
Addition polymerization
Block copolymers
Diimide
Infrared imaging
Medical imaging
Micelles
Nanoparticles
Naphthalene
Near infrared radiation
Polymer chemistry
Polymers
Self-assembly
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Summary:Although semiconducting polymer nanoparticles (SPN) are emerging as versatile theragnostic platforms for drug delivery and near infrared (NIR)-imaging, their synthesis remains restricted to nanoprecipatation or graft polymers. Here we present a novel method for creating an SPN of the donor-acceptor conjugated polymer p(IDT-NDI) containing indacenodithienothiophene (IDT) and naphthalene diimide (NDI) units. The conjugated polymer is functionalised with a styryl endgroup which is used to introduce a RAFT-agent via a 1,2-radical insertion reaction. This results in a conjugated macroinitiator which can be chain extended using classical RAFT polymerization with methyl acrylate resulting in an amphiphillic triblock copolymer. The amphiphile showed excellent self-assembly with stable particles of 80-110 nm diameter and absorption and emission in the NIR-region. The micelles are taken up efficiently by cells and can deliver a payload proving this method to be a new and powerful tool for the future of SPN in bioimaging. A novel method for creating a semiconducting nanoparticles of the donor-acceptor conjugated polymer p(IDT-NDI) containing indacenodithienothiophene (IDT) and naphthalene diimide (NDI) units is presented.
ISSN:1759-9954
1759-9962
DOI:10.1039/d2py00258b