Injectable Acylhydrazone‐Linked RAFT Polymer Hydrogels for Sustained Protein Release and Cell Encapsulation (Adv. Healthcare Mater. 7/2022)

Injectable Hydrogels In article number 2101284 by Chien‐Chi Lin and co‐workers, a biocompatible and pH/thermo dual responsive injectable hydrogel is synthesized by reversible addition‐fragmentation chain‐transfer (RAFT) polymerization and acylhdrazone click chemistry. Upon injection, sol‐gel transit...

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Bibliographic Details
Published in:Advanced healthcare materials 2022-04, Vol.11 (7), p.n/a
Main Authors: Lin, Fang‐Yi, Dimmitt, Nathan H., Moraes de Lima Perini, Mariana, Li, Jiliang, Lin, Chien‐Chi
Format: Article
Language:English
Subjects:
Addition polymerization
Biocompatibility
Body temperature
Chemical synthesis
Hydrogels
pH effects
Polymers
Proteins
Sol-gel processes
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Summary:Injectable Hydrogels In article number 2101284 by Chien‐Chi Lin and co‐workers, a biocompatible and pH/thermo dual responsive injectable hydrogel is synthesized by reversible addition‐fragmentation chain‐transfer (RAFT) polymerization and acylhdrazone click chemistry. Upon injection, sol‐gel transition occurs rapidly at body temperature and the porous hydrogels degrade slowly under mild acidic condition due to pH‐sensitive cleavages of acylhydrazone bonds. The slow hydrogel degradation may be leveraged for long‐term sustained protein delivery.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202270035