Optimized-dose lidocaine-loaded sulfobutyl ether β-cyclodextrin/hyaluronic acid hydrogels to improve physical, chemical, and pharmacological evaluation for local anesthetics and drug delivery systems

• Published in: Journal of materials science 2022-04, Vol.57 (13), p.7068-7084
• Main Authors: Zhou, Li-Yuan, Wang, Yan-Hong, Pan, Rong-Rong, Wan, Zhan-Hai, Zhang, Meng-Jie, Liu, Ya-Tao
• Format: Article
• Language: English
• Subjects: Analgesia; Analgesics; Anesthetics; Biocompatibility; Biodegradability; Characterization and Evaluation of Materials; Chemistry and Materials Science; Classical Mechanics; Crosslinking; Crystallography and Scattering Methods; Cyclodextrins; Cytotoxicity; Diffraction patterns; Drug delivery systems; Fourier transforms; Hyaluronic acid; Hydrogels; Materials for Life Sciences; Materials Science; Polymer Sciences; Rheological properties; Solid Mechanics; Toxicity
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1007/s10853-022-07072-4

Local anesthetics (LAs) are a class of drugs, which have wide applications in the treatment of post-operative pain care management. Long-acting LAs that can be given as a single dose analgesic are desperately needed. The prepared sulfobutylether β -cyclodextrin (SCD)/hyaluronic acid (HA) hydrogels were characterized by Fourier transform infrared and X-ray diffraction patterns. The as-prepared SCD/HA hydrogels greatly enhanced their swelling behavior and in vitro degradation properties. Furthermore, a scanning electron microscope reported that the surface morphology of the Lidocaine (LDC)-loaded SCD/HA hydrogels was smooth, and a significant change in porosity was observed after the addition of LDC (0.5%, 1.0%, and 1.5% w/v). The occurrence of cross-linking between the LDC and SCD/HA hydrogels was studied through rheological analysis. Approximately 94% of lidocaine (LDC) was released from the SCD/HA-LDC formulations by 24 h. The cytotoxicity of SCD/HA-LDC was studied against fibroblast (3T3) cells. SCD/HA-LDC showed a prolonged in vitro release and lower cytotoxicity when compared to free LDC. Furthermore, in vivo evaluation of the anesthetic properties in animal models showed that the SCD/HA-LDC showed a significantly prolonged analgesic effect when compared to free LDC. Moreover, the SCD/HA-LDC exhibited good biodegradability and biocompatibility in histological analyses. Overall, the findings suggest that the LDC-loaded SCD/HA hydrogels had a synergistic impact in prolonging analgesia without generating toxicity, and hence might be used as a long-acting analgesia therapeutic care. Graphical abstract