Endobronchial ultrasound‐guided fine needle aspiration diagnosis of metastatic FUS‐ERG‐rearranged extraskeletal Ewing sarcoma following 15 years of untreated metastatic recurrence

This case report demonstrates challenges in the cytological diagnosis of metastatic extraskeletal Ewing sarcoma from an endobronchial ultrasound‐guided fine needle aspiration biopsy and the important role of ancillary molecular analysis. It also adds to the small number of Ewing sarcoma with FUS‐ERG...

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Published in:Cytopathology (Oxford) 2022-05, Vol.33 (3), p.389-392
Main Authors: Wang, Chiyun, Dickson, Brendan C., Smith, Adam C., Hope, Andrew J., Ko, Hyang Mi
Format: Article
Language:English
Subjects:
Biopsy
Bronchoscopy
Diagnosis
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Ewing's sarcoma
Ewings sarcoma
FUS protein
Humans
Lung Neoplasms - pathology
Metastases
Metastasis
RNA-Binding Protein FUS
Sarcoma, Ewing - diagnosis
Sarcoma, Ewing - genetics
Sarcoma, Ewing - pathology
Transcriptional Regulator ERG
Ultrasonic imaging
Ultrasonography
Ultrasound
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container_issue 3
container_start_page 389
container_title Cytopathology (Oxford)
container_volume 33
creator Wang, Chiyun
Dickson, Brendan C.
Smith, Adam C.
Hope, Andrew J.
Ko, Hyang Mi
description This case report demonstrates challenges in the cytological diagnosis of metastatic extraskeletal Ewing sarcoma from an endobronchial ultrasound‐guided fine needle aspiration biopsy and the important role of ancillary molecular analysis. It also adds to the small number of Ewing sarcoma with FUS‐ERG fusion in the literature by highlighting an exceptionally indolent clinical course over 15 years of slowly progressing pulmonary metastases in the absence of any treatment.
doi_str_mv 10.1111/cyt.13074
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subjects Biopsy
Bronchoscopy
Diagnosis
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Ewing's sarcoma
Ewings sarcoma
FUS protein
Humans
Lung Neoplasms - pathology
Metastases
Metastasis
RNA-Binding Protein FUS
Sarcoma, Ewing - diagnosis
Sarcoma, Ewing - genetics
Sarcoma, Ewing - pathology
Transcriptional Regulator ERG
Ultrasonic imaging
Ultrasonography
Ultrasound
title Endobronchial ultrasound‐guided fine needle aspiration diagnosis of metastatic FUS‐ERG‐rearranged extraskeletal Ewing sarcoma following 15 years of untreated metastatic recurrence
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