In situ synthesis of a functional ZIF-8 nanocomposite for synergistic photodynamic–chemotherapy and pH and NIR-stimulated drug release

In this paper, we designed and synthesized a novel pH and NIR light responsive UCNP/TiO 2 /Cur@ZIF-8 nano-composite. The newly synthesized nano-platform was characterized using spectroscopic methods. Here, upconversion nanoparticles (UCNPs) and titanium dioxide nanoparticles (TiO 2 NPs) were encapsu...

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Bibliographic Details
Published in:New journal of chemistry 2022-04, Vol.46 (15), p.6966-6970
Main Authors: Wen, Xin, Liu, Ning, Ren, Jia, Jiao, Xiaorui, Lv, Junying, Akhtar, Mahmood Hassan, Qi, Hong, Zhu, Jianwei, Yu, Cong, Li, Yunhui
Format: Article
Language:English
Subjects:
Nanocomposites
Nanoparticles
Near infrared radiation
Synthesis
Titanium dioxide
Tumors
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Summary:In this paper, we designed and synthesized a novel pH and NIR light responsive UCNP/TiO 2 /Cur@ZIF-8 nano-composite. The newly synthesized nano-platform was characterized using spectroscopic methods. Here, upconversion nanoparticles (UCNPs) and titanium dioxide nanoparticles (TiO 2 NPs) were encapsulated to upconvert energy through the photosensitizing phenomenon where the chemotherapeutic agent curcumin (Cur) and TiO 2 synergistically achieved therapeutic effects. At first, ZIF-8 decomposed in the acidic microenvironment of tumors that assisted TiO 2 NPs to efficiently convert the irradiated near infrared (NIR) 808 nm light into UV visible light, thus producing a large number of reactive oxygen species to effectively inhibit tumor growth. Furthermore, in vitro and in vivo data demonstrated that UCNP/TiO 2 /Cur@ZIF-8 is an excellent nanoplatform that can be used as NIR-mediated photodynamic as well as chemotherapeutic therapy for tumors.
ISSN:1144-0546
1369-9261
DOI:10.1039/D2NJ00082B