Three-dimensional gradient porous polymeric composites for osteochondral regeneration

Poly (ε-caprolactone, PCL) matrix composite scaffolds with controlled gradient pore structure (GPS) were prepared by 3D printing. It is shown that GPS stimulates the osteogenic and chondrogenic differentiation of mesenchymal stem cells (MSCs) in vitro. Curvature-assisted biomineralization and the ef...

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Bibliographic Details
Published in:Journal of polymer research 2022-05, Vol.29 (5), Article 163
Main Authors: Tamjid, Elnaz, Marzooghi, Shadi, Najafi, Parvin, Behmanesh, Mehrdad
Format: Article
Language:English
Subjects:
3D printing
Bioglass
Biological products
Biomedical materials
Cell differentiation
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Differentiation (biology)
Industrial Chemistry/Chemical Engineering
Polymer Sciences
Porosity
Regeneration
Short Communication
Stem cells
Three dimensional composites
Three dimensional printing
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Summary:Poly (ε-caprolactone, PCL) matrix composite scaffolds with controlled gradient pore structure (GPS) were prepared by 3D printing. It is shown that GPS stimulates the osteogenic and chondrogenic differentiation of mesenchymal stem cells (MSCs) in vitro. Curvature-assisted biomineralization and the effect of pore sizes are elaborated. Different effects of nanobioceramics (Bioglass and Titania) on the cell differentiation and tissue-ingrowth kinetics are reported. The fabricated GPS biomaterials by additive manufacturing could provide a new pathway for osteochondral regeneration.
ISSN:1022-9760
1572-8935
DOI:10.1007/s10965-022-02989-5