Microwave-Assisted Synthesis of Some Novel 1,2,3,4-Tetrahydropyrimidine Derivatives as Antidiabetic Agents

An efficient and rapid microwave irradiation protocol have been developed for the synthesis of a new series of N -(4-R-phenyl)-6-methyl-4-(4-{[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}phenyl)-2-oxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides. The synthesized compounds were evaluated f...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2022-03, Vol.58 (3), p.356-362
Main Authors: Vachhani, M. D., Lalpara, J. N., Hadiyal, S. D., Dubal, G. G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
Synthesis
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Summary:An efficient and rapid microwave irradiation protocol have been developed for the synthesis of a new series of N -(4-R-phenyl)-6-methyl-4-(4-{[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}phenyl)-2-oxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamides. The synthesized compounds were evaluated for their in vitro antidiabetic activity by the α-amylase inhibition assay, and some derivatives exhibited a significant antidiabetic activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022030137