Synthesis and Antibacterial Activity of Pyranopyrimidinedione Derivatives

Four pyranopyrimidinedione derivatives were prepared through a one-pot pseudo-three-component acetic acid-catalyzed reaction of 6-amino-1,3-dimethyluracil with 2-hydroxybenzaldehydes. The synthesized compounds were evaluated for their antibacterial activity against a panel of bacterial strains. The...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2022-03, Vol.58 (3), p.372-378
Main Authors: Azarkamanzad, Z., Farzaneh, F., Ghandi, M., Feizabadi, M. M., Jasemi, S.
Format: Article
Language:English
Subjects:
Acetic acid
Chemistry
Chemistry and Materials Science
Hydroxybenzaldehydes
Organic Chemistry
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Summary:Four pyranopyrimidinedione derivatives were prepared through a one-pot pseudo-three-component acetic acid-catalyzed reaction of 6-amino-1,3-dimethyluracil with 2-hydroxybenzaldehydes. The synthesized compounds were evaluated for their antibacterial activity against a panel of bacterial strains. The minimum inhibitory concentrations (MICs) were determined using broth microdilution assay according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. With the exception of 5-methoxy derivative, the other pyranopyrimidinediones exhibited antibacterial activities against all tested bacterial cultures. The most potent antibacterial effect was observed for 5-bromopyranopyrimidinedione derivative against clinical strains, which can be regarded as promising.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022030162