Effect of Chysophyllum albidum Ethanol Leaf Extract on Haematological and Platelet Indices of Apparently Healthy Wistar Rat

Chysophyllum albidum ethanol leaf extract was studied to ascertain it potentials on hematological indices and hepatocyte of wistar albino rat. Twenty-five rats that weighed 98-168g were separated into five groups. Phytochemicals were quantified using standard methods. Alkaloids, flavonoids, tannins,...

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Bibliographic Details
Published in:Pakistan journal of zoology 2022-06, Vol.54 (3), p.1095
Main Authors: Ozioko, Juliet N, Ayogu, Obinna V, Ezema, Benjamin O, Uramah, Dilibe C, Omeje, Kingsley O
Format: Article
Language:English
Subjects:
Acids
Alanine
Alanine transaminase
Alcohol
Alcohol, Denatured
Alkaloids
Antimicrobial agents
Antioxidants
Aspartate transaminase
Blood
Blood platelets
Catalase
Chemical properties
Dosage and administration
Enzymes
Ethanol
Flavonoids
Health aspects
Hematology
Hemoglobin
Leaves
Leukocytes
Mass spectroscopy
Oral administration
Pharmaceutical research
Phenols
Phytochemicals
Phytol
Plant extracts
Platelets
Rats
Rattus
Steroids
Superoxide dismutase
Tannins
Transaminase
Tropical diseases
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Summary:Chysophyllum albidum ethanol leaf extract was studied to ascertain it potentials on hematological indices and hepatocyte of wistar albino rat. Twenty-five rats that weighed 98-168g were separated into five groups. Phytochemicals were quantified using standard methods. Alkaloids, flavonoids, tannins, saponnins and terpernoids were detected. The leaf extract had 0.415 % of alkaloids, 0.102 mg/TAEq of tannins, 0.211 mg/QEq of flavonoids and 0.360 mg/GAEq of phenolics. Phytol, oleic acids, hexadecanoic acids and octadecanoic acids were detected in the leaf extract by Gas Chomatography-Mass Spectroscopy. White blood cells, hemoglobin and platelets were some of the hematological indices increased after the oral administration of the extract. Red cell distribution width (RDW), a platelet index implicated in cardiovascular ailments was lowered after consumption of the leaf extract of C. albidum. The liver marker enzymes aspartate transaminase and alanine transaminase showed no significant changes in their serum activity. Similarly, superoxide dismutase and catalase showed no significant increase after the period of study. Keywords: Platelet indices, hematological indices, Phytomedicine, Chysophyllum albidum, Enzymes
ISSN:0030-9923
0030-9923
DOI:10.17582/journal.pjz/20201003141005