Effect of ammonium chloride addition on crystal growth, structural, optical and biological applications of L-glutamic acid crystals

• Published in: Applied physics. A, Materials science & processing Materials science & processing, 2022-05, Vol.128 (5), Article 416
• Main Authors: Vijayalakshmi, V., Dhanasekaran, P., Aarthi, J.
• Format: Article
• Language: English
• Subjects: Acids; Ammonium chloride; Anticancer properties; Applied physics; Aqueous solutions; Characterization and Evaluation of Materials; Chloride; Chlorides; Condensed Matter Physics; Crystal growth; Crystal structure; Crystals; Fourier transforms; Functional groups; Glutamic acid; Infrared analysis; Machines; Manufacturing; Materials science; Nanotechnology; Optical and Electronic Materials; Physics; Physics and Astronomy; Processes; Spectrum analysis; Surfaces and Interfaces; Thin Films
• ISSN: 0947-8396; 1432-0630
• DOI: 10.1007/s00339-022-05467-3

In this present work, the crystals of β and α polymorphs of L -glutamic acid were grown by the slow evaporation method with addion of ammonium chloride. The selective additive ammonium chloride was mixed at proportions 0.01 g, 0.02 g, 0.03 g,…, 0.10 g into the L -glutamic acid aqueous solution to find out the α and β polymorphs of L -glutamic acid. The lower proportion (0.01 g) of ammonium chloride yields β polymorph, whereas higher proportion (0.08 g) of ammonium chloride yields α polymorph of L -glutamic acid that was confirmed by powder XRD studies. UV–Vis–NIR spectral analysis shows a good optical transparency of the grown crystals of α and β polymorphs in visible and infrared regions. The functional groups present in the crystal were identified by Fourier-transform infrared spectroscopy (FTIR) analysis. The antibacterial activities of grown crystals against Gram-negative bacterial strains were carried out using the agar disk diffusion method. The anticancer activity study shows that both polymorphs inhibit the human breast cancer cell line.