Metathesis Reactions in Natural Product Fragments and Total Syntheses

• Published in: Asian journal of organic chemistry 2022-04, Vol.11 (4), p.n/a
• Main Authors: Ahmed, Waqar, Jayant, Vikrant, Alvi, Shakeel, Ahmed, Nadeem, Ahmed, Azeem, Ali, Rashid
• Format: Article
• Language: English
• Subjects: Chemical reactions; Chemical synthesis; Chemists; Complexity; Cross metathesis; Fragments; Metathesis; Natural product fragments; Natural products; Organic chemistry; Ring-closing alkyne metathesis; Ring-closing enyne metathesis; Ring-closing metathesis; Tactics; Total synthesis
• ISSN: 2193-5807; 2193-5815
• DOI: 10.1002/ajoc.202100753

The passion of total‐ and fragments syntheses of natural products always remained one of the top priorities among the synthetic chemists worldwide. Due their curiosity toward the complexity of molecules of living nature and their endeavour to imitate them in laboratory; limitless arrays of natural products have been extracted, architecturally‐elucidated, synthesized, and chronicled by utilizing various synthetic methodologies in different fashions. Frequently, the synthesis of complex natural products proceed with inscrutable synthetic challenges, which can be circumvented either by modification of previously developed synthetic methods or by formulating a new one. In this way, a myriad of powerful synthetic reactions have been developed since the genesis of the logic of chemical synthesis. Amongst them, metathesis tactics discovered unexpectedly in the 1950s (Nobel Prize in 2005), have incredibly influenced and changed the landscape of the art of the total and formal synthesis in the last three A. H. Hoveyda, A. R. Zhugralin, me abruptly as compared to other developed transformations or their modified forms. In this particular review article, we envisioned to report a comprehensive detail of the metathetic tools involved in both total and fragments synthesis of natural products in the years 2018 and 2019 along with an overview of 2017. A comprehensive review article covering the total‐ and formal syntheses of diverse valued natural products by means of metathesis reactions has been systematically presented for the years of 2018 and 2019 accompanied by an overview of the year 2017.