5-Hydroxy-1-phenylimidazolidine-2-thione as a new amidoalkylating agent for heterocyclic compounds

We showed a possibility of using 5-hydroxy-1-phenylimidazolidine-2-thione as an amidoalkylating agent in the reactions with 1-methyloxindole, 3-pyrazolone, and pyrazole derivatives to obtain a number of new unsymmetric bis-heterocyclic compounds with a direct C-C bond containing a combination of pha...

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Bibliographic Details
Published in:Russian chemical bulletin 2022-03, Vol.71 (3), p.587-590
Main Authors: Kochetkov, K. A., Gorunova, O. N., Bystrova, N. A.
Format: Article
Language:English
Subjects:
Brief Communications
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Heterocyclic compounds
Inorganic Chemistry
Organic Chemistry
Pyrazole
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Summary:We showed a possibility of using 5-hydroxy-1-phenylimidazolidine-2-thione as an amidoalkylating agent in the reactions with 1-methyloxindole, 3-pyrazolone, and pyrazole derivatives to obtain a number of new unsymmetric bis-heterocyclic compounds with a direct C-C bond containing a combination of pharmacophoric groups of two classes of heterocycles.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3454-x