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Novel fluoroquinolones containing 2‐arylamino‐2‐oxoethyl fragment: Design, synthesis, evaluation of antibacterial and antituberculosis activities and molecular modeling studies

Novel substituted fluoroquinolone derivatives, compounds 6–20 were designed, synthesized, and evaluated for antituberculosis and antibacterial activity. Antibacterial activities of the compounds were determined and compound 14 was found to be the most potent antimicrobial agent owing to minimal inhi...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2022-05, Vol.59 (5), p.909-926
Main Authors: Kulabaş, Necla, Türe, Aslı, Bozdeveci, Arif, Krishna, Vagolu Siva, Alpay Karaoğlu, Şengül, Sriram, Dharmarajan, Küçükgüzel, İlkay
Format: Article
Language:English
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Summary:Novel substituted fluoroquinolone derivatives, compounds 6–20 were designed, synthesized, and evaluated for antituberculosis and antibacterial activity. Antibacterial activities of the compounds were determined and compound 14 was found to be the most potent antimicrobial agent owing to minimal inhibitory concentration (MIC) value of
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4430