The relationship between metabolic syndrome and TIMI risk score in nondiabetic patients with acute coronary syndrome

• Published in: Türk Kardiyoloji Derneği arşivi 2007-06, Vol.35 (4), p.231
• Main Authors: Nurkalem, Zekeriya, Orhan, Ahmet Lütfü, Ahmet Taha Alper, Uslu, Nevzat, Aksu, Hüseyin, Gürdoğan, Muhammed, Şahin, İrfan, Erer, Betül, Görgülü, Şevket, Eren, Mehmet
• Format: Article
• Language: eng ; tur
• Subjects: Acute coronary syndromes; Angina pectoris; Fasting; Glucose; Metabolic syndrome
• ISSN: 1016-5169; 1308-4488

Objectives: We compared fasting and postprandial glycemia levels and their correlation with the TIMI risk score in nondiabetic patients with metabolic syndrome (MS). Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with unstable angina pectoris and acute myocardial infarction without ST elevation. TIMI risk scores were calculated on admission and coronary angiographies were evaluated. Prior to discharge, fasting glucose levels and lipid parameters were estimated and oral glucose tolerance test (OGTT) was performed. The presence of metabolic syndrome was determined in two ways: first using the ATP III criteria, and then using the same criteria, but with impaired glucose tolerance (GT) instead of impaired fasting glucose. Results: According to the ATP III criteria, MS was diagnosed in 30 patients (41.1%). The mean TIMI risk score in these patients was higher than that of patients without MS, but this did not reach a significant level (p=0.052). When impaired GT was included into the MS criteria instead of impaired fasting glucose, the number of patients with MS increased to 34 (46.6%), at which time the mean TIMI risk score showed a significant rise in the MS group (p=0.017). In multivariate analysis, the number of stenotic vessels (OR 3.02, p=0.02, 95% CI: 1.91-7.64) and postprandial glucose level (OR 1.040, p