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The relationship between metabolic syndrome and TIMI risk score in nondiabetic patients with acute coronary syndrome
Objectives: We compared fasting and postprandial glycemia levels and their correlation with the TIMI risk score in nondiabetic patients with metabolic syndrome (MS). Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with un...
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Published in: | Türk Kardiyoloji Derneği arşivi 2007-06, Vol.35 (4), p.231 |
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creator | Nurkalem, Zekeriya Orhan, Ahmet Lütfü Ahmet Taha Alper Uslu, Nevzat Aksu, Hüseyin Gürdoğan, Muhammed Şahin, İrfan Erer, Betül Görgülü, Şevket Eren, Mehmet |
description | Objectives: We compared fasting and postprandial glycemia levels and their correlation with the TIMI risk score in nondiabetic patients with metabolic syndrome (MS). Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with unstable angina pectoris and acute myocardial infarction without ST elevation. TIMI risk scores were calculated on admission and coronary angiographies were evaluated. Prior to discharge, fasting glucose levels and lipid parameters were estimated and oral glucose tolerance test (OGTT) was performed. The presence of metabolic syndrome was determined in two ways: first using the ATP III criteria, and then using the same criteria, but with impaired glucose tolerance (GT) instead of impaired fasting glucose. Results: According to the ATP III criteria, MS was diagnosed in 30 patients (41.1%). The mean TIMI risk score in these patients was higher than that of patients without MS, but this did not reach a significant level (p=0.052). When impaired GT was included into the MS criteria instead of impaired fasting glucose, the number of patients with MS increased to 34 (46.6%), at which time the mean TIMI risk score showed a significant rise in the MS group (p=0.017). In multivariate analysis, the number of stenotic vessels (OR 3.02, p=0.02, 95% CI: 1.91-7.64) and postprandial glucose level (OR 1.040, p |
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Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with unstable angina pectoris and acute myocardial infarction without ST elevation. TIMI risk scores were calculated on admission and coronary angiographies were evaluated. Prior to discharge, fasting glucose levels and lipid parameters were estimated and oral glucose tolerance test (OGTT) was performed. The presence of metabolic syndrome was determined in two ways: first using the ATP III criteria, and then using the same criteria, but with impaired glucose tolerance (GT) instead of impaired fasting glucose. Results: According to the ATP III criteria, MS was diagnosed in 30 patients (41.1%). The mean TIMI risk score in these patients was higher than that of patients without MS, but this did not reach a significant level (p=0.052). When impaired GT was included into the MS criteria instead of impaired fasting glucose, the number of patients with MS increased to 34 (46.6%), at which time the mean TIMI risk score showed a significant rise in the MS group (p=0.017). In multivariate analysis, the number of stenotic vessels (OR 3.02, p=0.02, 95% CI: 1.91-7.64) and postprandial glucose level (OR 1.040, p<0.001, 95% CI: 1.018-1.063) were found as independent predictors of a high TIMI risk score. Conclusion: The incidence of MS is considerable in nondiabetic patients with acute coronary syndrome. The use of impaired GT instead of fasting glucose for the diagnosis of MS results in a better correlation with the TIMI risk score.</description><identifier>ISSN: 1016-5169</identifier><identifier>EISSN: 1308-4488</identifier><language>eng ; tur</language><publisher>Istanbul: Aves Yayincilik Ltd. STI</publisher><subject>Acute coronary syndromes ; Angina pectoris ; Fasting ; Glucose ; Metabolic syndrome</subject><ispartof>Türk Kardiyoloji Derneği arşivi, 2007-06, Vol.35 (4), p.231</ispartof><rights>2007. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2658081390?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,37012,44590</link.rule.ids></links><search><creatorcontrib>Nurkalem, Zekeriya</creatorcontrib><creatorcontrib>Orhan, Ahmet Lütfü</creatorcontrib><creatorcontrib>Ahmet Taha Alper</creatorcontrib><creatorcontrib>Uslu, Nevzat</creatorcontrib><creatorcontrib>Aksu, Hüseyin</creatorcontrib><creatorcontrib>Gürdoğan, Muhammed</creatorcontrib><creatorcontrib>Şahin, İrfan</creatorcontrib><creatorcontrib>Erer, Betül</creatorcontrib><creatorcontrib>Görgülü, Şevket</creatorcontrib><creatorcontrib>Eren, Mehmet</creatorcontrib><title>The relationship between metabolic syndrome and TIMI risk score in nondiabetic patients with acute coronary syndrome</title><title>Türk Kardiyoloji Derneği arşivi</title><description>Objectives: We compared fasting and postprandial glycemia levels and their correlation with the TIMI risk score in nondiabetic patients with metabolic syndrome (MS). Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with unstable angina pectoris and acute myocardial infarction without ST elevation. TIMI risk scores were calculated on admission and coronary angiographies were evaluated. Prior to discharge, fasting glucose levels and lipid parameters were estimated and oral glucose tolerance test (OGTT) was performed. The presence of metabolic syndrome was determined in two ways: first using the ATP III criteria, and then using the same criteria, but with impaired glucose tolerance (GT) instead of impaired fasting glucose. Results: According to the ATP III criteria, MS was diagnosed in 30 patients (41.1%). The mean TIMI risk score in these patients was higher than that of patients without MS, but this did not reach a significant level (p=0.052). When impaired GT was included into the MS criteria instead of impaired fasting glucose, the number of patients with MS increased to 34 (46.6%), at which time the mean TIMI risk score showed a significant rise in the MS group (p=0.017). In multivariate analysis, the number of stenotic vessels (OR 3.02, p=0.02, 95% CI: 1.91-7.64) and postprandial glucose level (OR 1.040, p<0.001, 95% CI: 1.018-1.063) were found as independent predictors of a high TIMI risk score. Conclusion: The incidence of MS is considerable in nondiabetic patients with acute coronary syndrome. The use of impaired GT instead of fasting glucose for the diagnosis of MS results in a better correlation with the TIMI risk score.</description><subject>Acute coronary syndromes</subject><subject>Angina pectoris</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Metabolic syndrome</subject><issn>1016-5169</issn><issn>1308-4488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNo9jc1qwzAQhE1poSHNOyz0bJAsWZaOJfQnkNKLew6yvMJKHcmVFELevoKWzmV2YObbm2pFGZE151LelptQUbdUqPtqk9KRFHHFaNutqtxPCBFnnV3waXILDJgviB5OmPUQZmcgXf0YwwlB-xH63fsOoktfkEyICM6DD350uuxKdykg9DnBxeUJtDlnhNILXsfrP-ihurN6Trj583X1-fLcb9_q_cfrbvu0rxdKWa6NGZQlqmWaKSo6S5Xk0jZkkGaw3ApOBtV1XcN1I6wtqYgLqzgxfERD2Lp6_OUuMXyfMeXDMZyjLy8PjWglkZQpwn4AD5Va-A</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Nurkalem, Zekeriya</creator><creator>Orhan, Ahmet Lütfü</creator><creator>Ahmet Taha Alper</creator><creator>Uslu, Nevzat</creator><creator>Aksu, Hüseyin</creator><creator>Gürdoğan, Muhammed</creator><creator>Şahin, İrfan</creator><creator>Erer, Betül</creator><creator>Görgülü, Şevket</creator><creator>Eren, Mehmet</creator><general>Aves Yayincilik Ltd. 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Study design: The study included 73 consecutive nondiabetic patients (9 women, 64 men; mean age 58±11 years) who were admitted with unstable angina pectoris and acute myocardial infarction without ST elevation. TIMI risk scores were calculated on admission and coronary angiographies were evaluated. Prior to discharge, fasting glucose levels and lipid parameters were estimated and oral glucose tolerance test (OGTT) was performed. The presence of metabolic syndrome was determined in two ways: first using the ATP III criteria, and then using the same criteria, but with impaired glucose tolerance (GT) instead of impaired fasting glucose. Results: According to the ATP III criteria, MS was diagnosed in 30 patients (41.1%). The mean TIMI risk score in these patients was higher than that of patients without MS, but this did not reach a significant level (p=0.052). When impaired GT was included into the MS criteria instead of impaired fasting glucose, the number of patients with MS increased to 34 (46.6%), at which time the mean TIMI risk score showed a significant rise in the MS group (p=0.017). In multivariate analysis, the number of stenotic vessels (OR 3.02, p=0.02, 95% CI: 1.91-7.64) and postprandial glucose level (OR 1.040, p<0.001, 95% CI: 1.018-1.063) were found as independent predictors of a high TIMI risk score. Conclusion: The incidence of MS is considerable in nondiabetic patients with acute coronary syndrome. The use of impaired GT instead of fasting glucose for the diagnosis of MS results in a better correlation with the TIMI risk score.</abstract><cop>Istanbul</cop><pub>Aves Yayincilik Ltd. STI</pub><oa>free_for_read</oa></addata></record> |
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subjects | Acute coronary syndromes Angina pectoris Fasting Glucose Metabolic syndrome |
title | The relationship between metabolic syndrome and TIMI risk score in nondiabetic patients with acute coronary syndrome |
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