3D Bioprinted GelMA‐Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells Through Activating Wnt/β‐Catenin Signaling (Small 18/2022)

Cancer Stem Cells In article number 2200364, Zhuo Xiong and co‐workers report that 3D bioprinted GelMA‐nanoclay hybrid hydrogels can induce and enrich colorectal cancer stem cells (CSCs) by promoting the formation of spheroids by activating Wnt/β‐catenin signaling. These spheroids can be isolated ea...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-05, Vol.18 (18), p.n/a
Main Authors: Zhang, Yanmei, Wang, Zixuan, Hu, Qifan, Luo, Hao, Lu, Bingchuan, Gao, Yunhe, Qiao, Zhi, Zhou, Yongsen, Fang, Yongcong, Gu, Jin, Zhang, Ting, Xiong, Zhuo
Format: Article
Language:English
Subjects:
3D bioprinting
Bioengineering
Cancer
cancer stem cells
Colorectal cancer
GelMA‐nanoclay hydrogels
Hydrogels
Nanotechnology
Signaling
Spheroids
Stem cells
Three dimensional printing
Wnt/β‐catenin signaling
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Summary:Cancer Stem Cells In article number 2200364, Zhuo Xiong and co‐workers report that 3D bioprinted GelMA‐nanoclay hybrid hydrogels can induce and enrich colorectal cancer stem cells (CSCs) by promoting the formation of spheroids by activating Wnt/β‐catenin signaling. These spheroids can be isolated easily and are promising CSC enrichment models with increased stemness, high consistency, yield and efficiency for targeting CSC drug screening.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202270089