Thermochemical analysis of intermolecular interactions of L-carnosine with isonicotinic acid in aqueous solutions

Investigation of the interactions between pyridine derivatives and model compounds of protein, as dipeptides and oligopeptides, is of special interest for pharmaceutical applications. Studies on physicochemical properties of their aqueous solutions play key role in understanding the nature of molecu...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2022-06, Vol.147 (11), p.6461-6467
Main Authors: Krutova, O. N., Usacheva, T. R., Myshenkov, M. S., Niccoli, M., Giancola, C.
Format: Article
Language:English
Subjects:
Amino acids
Analytical Chemistry
Aqueous solutions
Chemistry
Chemistry and Materials Science
Enthalpy
Inorganic Chemistry
Measurement Science and Instrumentation
Molecular interactions
Physical Chemistry
Polymer Sciences
Proteins
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Summary:Investigation of the interactions between pyridine derivatives and model compounds of protein, as dipeptides and oligopeptides, is of special interest for pharmaceutical applications. Studies on physicochemical properties of their aqueous solutions play key role in understanding the nature of molecular interactions in liquid mixtures. Here the calorimetric method was used to measure the enthalpy of mixing in aqueous solutions of the dipeptide L-carnosine with the drug isonicotinic acid. The data were analyzed based on the McMillan–Mayer theory to obtain the cross-pair interaction coefficient, h xy , that indicates relatively strong interactions with predominant hydrophilic specific interactions.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-021-10982-1