Protective effect of food derived nutrients on cisplatin nephrotoxicity and its mechanism

Platinum-based metal complexes, especially cisplatin ( cis -diamminedichloroplatinum II, CDDP), possess strong anticancer properties and a broad anticancer spectrum. However, the clinical application of CDDP has been limited by its side effects including nephrotoxicity, ototoxicity, and neurotoxicit...

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Bibliographic Details
Published in:Food & function 2022-05, Vol.13 (9), p.4839-486
Main Authors: Liu, Chaofan, Zhou, Sajin, Bai, Weibin, Shi, Lei, Li, Xiaoling
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - adverse effects
Apoptosis
Cancer
Cisplatin
Cisplatin - adverse effects
Coordination compounds
Humans
Kidney
Metal complexes
Molecular modelling
Neurotoxicity
Nutrients
Nutrition
Ototoxicity
Oxidative stress
Platinum
Side effects
Target recognition
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Summary:Platinum-based metal complexes, especially cisplatin ( cis -diamminedichloroplatinum II, CDDP), possess strong anticancer properties and a broad anticancer spectrum. However, the clinical application of CDDP has been limited by its side effects including nephrotoxicity, ototoxicity, and neurotoxicity. Furthermore, the therapeutic effects of current clinical protocols are imperfect. Accordingly, it is essential to identify key targets and effective clinical protocols to restrict CDDP-induced nephrotoxicity. Herein, we first analyzed the relevant molecular mechanisms during the process of CDDP-induced nephrotoxicity including oxidative stress, apoptosis, and inflammation. Evidence from current studies was collected and potential targets and clinical protocols are summarized. The evidence indicates an efficacious role of nutrition-based substances in CDDP-induced renal injury. Platinum-based metal complexes, especially cisplatin ( cis -diamminedichloroplatinum II, CDDP), possess strong anticancer properties and a broad anticancer spectrum.
ISSN:2042-6496
2042-650X
DOI:10.1039/d1fo04391a