Lignans and sesquiterpenes from Schisandra tomentella A. C. Smith

This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1–2), and two new sesquiterpenoids, tomentaschinnes A-B (3–4). Their structure...

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Bibliographic Details
Published in:Fitoterapia 2022-04, Vol.158, p.105142, Article 105142
Main Authors: Wu, Cai-Meng, Chu, Wang, Chen, Yi-Li, Liang, Dong-E, Qiu, Fei-Jun, Zhan, Zha-Jun, Ma, Lie-Feng
Format: Article
Language:English
Subjects:
Cytotoxicity
Lignan
Lignans
MDR reversal
Multidrug resistance
Schisandra
Schisandra tomentella
Sesquiterpenes
Sesquiterpenoid
Sesquiterpenoids
Toxicity
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Summary:This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1–2), and two new sesquiterpenoids, tomentaschinnes A-B (3–4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M2 (7) could promote the efficacy of adriamycin against MCF-7/ADR. [Display omitted] •The first phytochemical investigation of Schisandra tomentella A. C. Smith were reported.•11 lignans and 8 sesquiterpenoids were isolated, including two undescribed lignans, and two new sesquiterpenoids.•Gomisin M2, with no obvious cytotoxicity, could promote the efficacy of anticancer drug adriamycin on MDR cell MCF-7/ADR at 20 μM.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2022.105142