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Construction of polysaccharide based physically crosslinked double-network antibacterial hydrogel

•A novel physically-crosslinked double-network hydrogel.•Facile preparation method.•The hydrogel showed good mechanical property.•The hydrogel showed excellent antibacterial activity. Most hydrogels are chemically crosslinked hydrogels, the use of excessive chemical crosslinkers limits their applica...

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Bibliographic Details
Published in:Materials letters 2022-06, Vol.316, p.132048, Article 132048
Main Authors: Shi, Chao, Yang, Faming, Hu, Le, Wang, Hongbo, Wang, Yuxin, Wang, Zhouchi, Pan, Shihui, Chen, Jingdi
Format: Article
Language:English
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Summary:•A novel physically-crosslinked double-network hydrogel.•Facile preparation method.•The hydrogel showed good mechanical property.•The hydrogel showed excellent antibacterial activity. Most hydrogels are chemically crosslinked hydrogels, the use of excessive chemical crosslinkers limits their application in biomedicine and other fields. Herein, a completely physically crosslinked double-network hydrogel of sodium alginate/chitosan/zinc ion (SA/CS/Zn2+ PDH) which does not contain toxic chemical reagents was prepared. Compared with the sodium alginate/chitosan single-network hydrogel crosslinked by electrostatic interactions, the mechanical properties of the PDH is significantly improved. Gelation time, swelling behavior, mechanical performance, and antibacterial ability were evaluated with zinc concentration as a variable. It was found that with the increase of zinc content, the gelation rate increased, the swelling rate decreased, and the mechanical properties improved. The PDH exhibited outstanding antibacterial activity against both Staphylococcus aureus and Escherichia coli. Our work provides a new idea for the fabrication of environment-friendly physically crosslinked double-network hydrogels based on natural polysaccharides.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2022.132048