Risperidone in analgesia induced by paracetamol and meloxicam in experimental pain

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the best therapeutic options to treat pain. Their use in combination with other drugs may broaden their applicability in analgesia if their ceiling and adverse effects are reduced. The aim of this study was to evaluate the pharmacological inter...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2022-06, Vol.36 (3), p.494-500
Main Authors: Miranda, Hugo F., Noriega, Viviana, Sierralta, Fernando, Sotomayor‐Zárate, Ramón, Prieto, Juan Carlos
Format: Article
Language:English
Subjects:
Acetaminophen - pharmacology
Analgesia
Analgesics
Animals
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antipsychotics
Drug dosages
Drugs
Inflammation
Meloxicam
Meloxicam - pharmacology
Meloxicam - therapeutic use
Mice
Nonsteroidal anti-inflammatory drugs
Pain
Pain - drug therapy
Pain perception
Paracetamol
Pharmacology
phasic pain
Risperidone
Risperidone - pharmacology
Risperidone - therapeutic use
tonic pain
Variance analysis
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Summary:Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the best therapeutic options to treat pain. Their use in combination with other drugs may broaden their applicability in analgesia if their ceiling and adverse effects are reduced. The aim of this study was to evaluate the pharmacological interaction of two NSAIDs, paracetamol and meloxicam, with the antipsychotic drug risperidone in mice, in several experimental tests of nociceptive and inflammatory pain. Antinociception was assessed by dose–response curves to paracetamol and meloxicam before and after the i.p. administration of 0.5 mg/kg of risperidone. Results are presented as means ± SEM and differences were calculated by one‐way ANOVA followed by Tukey's post‐test. Paracetamol and meloxicam produced a dose‐related antinociceptive effect with diverse potencies. Risperidone increased the analgesia mediated by paracetamol and meloxicam only in the tonic tests that detected inflammatory pain. This suggests that COX inhibition is only a partial explanation of the increased analgesic potency of paracetamol and meloxicam since the effects of NSAIDs in the CNS are mediated by multiple mechanisms. These results indicate that the combination of risperidone with paracetamol or meloxicam could be a new and effective alternative for the management of inflammatory pain.
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12754