Synthesis of Diaryl Sulfides by Using Tetramethylthiuram Monosulfide (TMTM) as Organosulfur Source: A Practical C(sp2)−S Bond Construction

A protocol for synthesizing symmetrical thioethers by using a cheap organosulfur reagent (tetramethylthiuram monosulfide: TMTM) was developed. Both iodobenzenes and phenylboronic acids react well with TMTM, giving the target products with good to excellent yields. This method features simple perform...

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Bibliographic Details
Published in:European journal of organic chemistry 2022-05, Vol.2022 (18), p.n/a
Main Authors: Wang, Xi, Chen, Jin‐Quan, Yang, Xing‐Xing, Hao, Er‐Jun, Dong, Zhi‐Bing
Format: Article
Language:English
Subjects:
Catalysis
Chemical synthesis
Functional groups
Iodobenzene
Phenylboronic acid
Reagents
Synthesis
Tetramethylthiuram monosulfide
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Summary:A protocol for synthesizing symmetrical thioethers by using a cheap organosulfur reagent (tetramethylthiuram monosulfide: TMTM) was developed. Both iodobenzenes and phenylboronic acids react well with TMTM, giving the target products with good to excellent yields. This method features simple performance, wide functional group tolerance, and good to excellent yields, showing a potential application value for the synthesis of drug molecules. A protocol for synthesizing symmetrical thioethers by using a cheap organosulfur reagent (tetramethylthiuram monosulfide: TMTM) was developed. Both iodobenzenes and phenylboronic acids react well with TMTM, giving the target products with good to excellent yields. This method features simple performance, wide functional group tolerance and good to excellent yields, showing a potential application value for the synthesis of drug molecules.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202200015