cis-and trans-decahydro-1,6-naphthyridines. Stereoselective synthesis and stereochemistry

New 1,6-disubstituted trans-decahydro-1,6-naphthyridines were synthesized by stereoselective nucleophilic addition of hydride and cyanide ions to 1,2,3,4,5,6,7,8-octahydro-1,6-naphthyridines, and their predominant conformations were determined. Some trans-decahydro-1,6-naphthyridine derivatives were...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2006-06, Vol.42 (6), p.922-928
Main Authors: Esipova, T. V., Borisenko, A. A., Grishina, G. V.
Format: Article
Language:English
Subjects:
Organic chemistry
Stereochemistry
Stereoselectivity
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Summary:New 1,6-disubstituted trans-decahydro-1,6-naphthyridines were synthesized by stereoselective nucleophilic addition of hydride and cyanide ions to 1,2,3,4,5,6,7,8-octahydro-1,6-naphthyridines, and their predominant conformations were determined. Some trans-decahydro-1,6-naphthyridine derivatives were found to exhibit anti-HIV activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428006060194