Mitosis in neoplastic and hyperplastic imaginal discs ofDrosophila

Homozygosity for recessive mutations inDrosophila tumour suppressor genes likelethal giant larvae (Igl), lethal giant discs (Igd) orfat (ft) induce uncontrolled cell proliferations in the imaginal discs of the mutant larvae. Imaginal discs of larvae mutant forIgl tumour suppressor gene display neopl...

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Bibliographic Details
Published in:Journal of genetics 1997-12, Vol.76 (3), p.209-220
Main Authors: Mishra, Arati, Radhakrishnan, Verneth, Sardesai, Sunita, Agrawal, Namita, Sinha, Pradip
Format: Article
Language:English
Subjects:
Aneuploidy
Cell division
Chromosomes
Cytoskeleton
Genetics
Imaginal discs
Immunoglobulin D
Insects
Karyotypes
Kinases
Larvae
Mitosis
Mutants
Mutation
Tumor suppressor genes
Tumors
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Summary:Homozygosity for recessive mutations inDrosophila tumour suppressor genes likelethal giant larvae (Igl), lethal giant discs (Igd) orfat (ft) induce uncontrolled cell proliferations in the imaginal discs of the mutant larvae. Imaginal discs of larvae mutant forIgl tumour suppressor gene display neoplastic growths while those mutant forIgd orfat display hyperplastic growths. Results presented in this study reveal that mutant wing imaginal discs with neoplastic or hyperplastic overgrowths display high mitotic activity primarily during the extended period of larval life when their wild-type siblings have already pupariated. Both these categories of overgrowths show overall stability of the karyotypes and only low frequency of aneuploidy. The hyperplastic imaginal discs ofIgd orft mutant larvae displayed normal chromosome condensation. In contrast, the neoplastic imaginal discs ofIgl mutants showed high frequency of mitotic cells with undercondensed chromosomes. In this respect the neoplastic discs resemble malignant neuroblastomas of theIgl larvae which also display undercondensed chromosomes. These results thus suggest an indirect role of the cytoskeletal protein encoded byIgl tumour suppressor gene in aspects of normal chromosome condensation during mitosis.[PUBLICATION ABSTRACT]
ISSN:0022-1333
0973-7731
DOI:10.1007/BF02932219