Clinical evaluation of the effect of attenuation correction technique on18F-fluoride PET images

Objective: The purpose of this study is to evaluate effect of attenuation correction technique on^sup 18^F-fluoride positron emission tomography (PET).Methods: We performed PET scans after the injection of 185 MBq^sup 18^F-fluoride on 32 patients from October 20th, 2004 to April 13th, 2005. We calcu...

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Bibliographic Details
Published in:Annals of nuclear medicine 2007-02, Vol.21 (2), p.93, Article 93
Main Authors: Tayama, Yoshibumi, Takahashi, Nobukazu, Oka, Takashi, Takahashi, Akira, Aratake, Masato, Saitou, Tomoyuki, Inoue, Tomio
Format: Article
Language:English
Subjects:
Arthritis
Attenuation
Bones
Emission analysis
Femur
Fibula
Fluorides
Humerus
Lesions
Mandible
Mathematical analysis
Medical imaging
Metastases
Muscles
Paget's disease
Patients
Pelvis
Positron emission
Positron emission tomography
Radius
Ratios
Rheumatoid arthritis
Scapula
Skeletal muscle
Thorax
Tibia
Tomography
Ulna
Vertebrae
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Summary:Objective: The purpose of this study is to evaluate effect of attenuation correction technique on^sup 18^F-fluoride positron emission tomography (PET).Methods: We performed PET scans after the injection of 185 MBq^sup 18^F-fluoride on 32 patients from October 20th, 2004 to April 13th, 2005. We calculated bone-to-muscle ratios for the images with and without attenuation correction. We placed regions of interest (ROIs) on normal bone accumulation in 22 patients. The exclusion criteria were bone metastasis, Paget's disease, and rheumatoid arthritis. Several regions were chosen for ROI placement: skull, cervical vertebra, mandible, scapula, thoracic vertebra, rib, humerus, lumbar vertebra, radius, ulna, pelvis, femoral head, femoral shaft, tibia, and fibula. The count ratios of normal bones to gluteus muscle were calculated as bone-to-muscle ratios. The count ratios of abnormal skeletal lesions to gluteus muscles were calculated as bone-to-muscle ratios, while the count ratios of abnormal skeletal lesions to normal bones were calculated as bone-to-bone ratios.Results: PET images without attenuation correction showed significantly higher mean bone-to-muscle ratios than those with attenuation correction (p
ISSN:0914-7187
1864-6433
DOI:10.1007/BF03033986