Intravitreal triamcinolone acetonide for treatment of acute nonarteritic anterior ischemic optic neuropathy

To report on the use of intravitreal triamcinolone acetonide as treatment for nonarteritic anterior ischemic optic neuropathy (NAION). The interventional clinical case series included three patients with acute NAION who received an intravitreal injection of about 20 mg triamcinolone acetonide. At th...

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Published in:Graefe's archive for clinical and experimental ophthalmology 2007-05, Vol.245 (5), p.749-750
Main Authors: Jonas, Jost B, Spandau, Ulrich H, Harder, Bjoern, Sauder, Gangolf
Format: Article
Language:English
Subjects:
Acuity
Acute Disease
Aged
Arteritis - drug therapy
Arteritis - physiopathology
Glucocorticoids - therapeutic use
Humans
Injection
Injections
Ischemia
Middle Aged
Ophthalmology
Optic neuropathy
Optic Neuropathy, Ischemic - drug therapy
Optic Neuropathy, Ischemic - physiopathology
Patients
Treatment Outcome
Triamcinolone acetonide
Triamcinolone Acetonide - therapeutic use
Visual Acuity - drug effects
Visual Acuity - physiology
Vitreous Body
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Summary:To report on the use of intravitreal triamcinolone acetonide as treatment for nonarteritic anterior ischemic optic neuropathy (NAION). The interventional clinical case series included three patients with acute NAION who received an intravitreal injection of about 20 mg triamcinolone acetonide. At the end of follow-up at 3 months, 3.5 months and at 5 months after the injection, visual acuity had changed from 0.10 at baseline to 0.20 in the first patient, from 0.50 to 0.20 in the second patient, and from 0.16 to 0.20 in the third patient. One eye developed triamcinolone-induced ocular hypertension which was treated by topical antiglaucomatous medication. The clinical courses of all three patients presented suggest that an intravitreal high-dosage injection of triamcinolone acetonide may not be markedly effective in increasing visual acuity after acute NAION.
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-006-0332-4