The interactions of cobalt(II) with mitochondria from rat liver

The interactions of Co(2+) with mitochondria have been investigated. The results indicate that Co(2+) inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of...

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Bibliographic Details
Published in:Journal of biological inorganic chemistry 2007-06, Vol.12 (5), p.631-635
Main Authors: Bragadin, Marcantonio, Toninello, Antonio, Mancon, Mario, Manente, Sabrina
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - metabolism
Adenosine Triphosphatases - antagonists & inhibitors
Adenosine Triphosphatases - metabolism
Adenosine Triphosphate - biosynthesis
Animals
Carbon dioxide
Citric Acid Cycle - physiology
Cobalt
Cobalt - chemistry
Electron Transport - drug effects
Electron Transport - physiology
Energy Metabolism - physiology
Enzyme Inhibitors - pharmacology
Indicators and Reagents
Inorganic chemistry
Mitochondria
Mitochondria, Liver - chemistry
Mitochondrial Membranes - chemistry
Oxygen Consumption - physiology
Permeability
Rats
Rats, Wistar
Spectrophotometry, Ultraviolet
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Summary:The interactions of Co(2+) with mitochondria have been investigated. The results indicate that Co(2+) inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP.
ISSN:0949-8257
1432-1327
DOI:10.1007/s00775-007-0222-1