Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization

Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The resu...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2022-03, Vol.15 (3), p.1085-1089
Main Authors: Kumar Gupta, Dinesh, Kumar Sharma, Satish, Kumar Gaur, Praveen, Singh, Alok Pratap
Format: Article
Language:English
Subjects:
Bioavailability
Lipids
Metabolism
Metabolites
Morphology
Nanoparticles
Particle size
Physiology
Solvents
Surfactants
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Summary:Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi’s kinetics for drug release.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2022.00181