Virgin Coconut Oil (VCO) Ameliorates High Fat Diet (HFD)-Induced Obesity, Dyslipidemia and Bestows Cardiovascular Protection in Rats

Effects of hot process-derived virgin coconut oil (VCO) on antiobesity, lipid-lowering and cardio-protection in male Wistar rat models fed with high-fat diet (HFD) were investigated for 7 weeks. The marked increase in body weight, liver weight, epididymal fat weight, and specific growth rate of HFD-...

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Published in:National Academy of Sciences, India. Proceedings. Section B. Biological Sciences India. Proceedings. Section B. Biological Sciences, 2022-06, Vol.92 (2), p.249-259
Main Authors: Shetty, Shilpa S., Roopashree, P. G., Ramesh, S. V., Singh, Ajeet, Arivalagan, M., Manikantan, M. R., Devi, Ullal Harshini, Sharmila, K. P., Hebbar, K. B., Kumari, N. Suchetha
Format: Article
Language:English
Subjects:
Animal models
Behavioral Sciences
Biomedical and Life Sciences
Body weight
Cardiovascular diseases
Cholesterol
Coconut oil
Dyslipidemia
Growth rate
High density lipoprotein
High fat diet
Life Sciences
Lipoproteins
Liver
Nucleic Acid Chemistry
Obesity
Plant Biochemistry
Research Article
Rodents
Triglycerides
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Summary:Effects of hot process-derived virgin coconut oil (VCO) on antiobesity, lipid-lowering and cardio-protection in male Wistar rat models fed with high-fat diet (HFD) were investigated for 7 weeks. The marked increase in body weight, liver weight, epididymal fat weight, and specific growth rate of HFD-fed rats were significantly attenuated when the HFD was supplemented with VCO. Serum lipid profile of VCO-fed rats showed significantly reduced levels of triglycerides, total cholesterol, low and very low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), and increment in high-density lipoprotein cholesterol (HDL-C) level. Significant decrease in cardiac risk indices and CHOLINDEX in all the VCO-treated animal groups were observed. Hepatic enzymatic biomarkers associated with HFD-induced liver damage were reversed with the VCO supplementation. Thus, dose-dependent VCO supplementation can be considered as an effective dietary approach to attenuate obesity and to alleviate the risks of cardiovascular diseases.
ISSN:0369-8211
2250-1746
DOI:10.1007/s40011-021-01318-y