Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions

We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplog...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2000-11, Vol.23 (10), p.671-676
Main Authors: Paracchini, S, Stuppia, L, Gatta, V, Palka, G, Moro, E, Foresta, C, Mengua, L, Oliva, R, Ballescà, J L, Kremer, J A, van Golde, R J, Tuerlings, J H, Hargreave, T, Ross, A, Cooke, H, Huellen, K, Vogt, P H, Tyler-Smith, C
Format: Article
Language:English
Subjects:
Chromosomes
Deoxyribonucleic acid
DNA
DNA - genetics
Europe
Gene Deletion
Gene Frequency
Haplotypes
Humans
Infertility, Male - genetics
Male
Males
Phylogeny
Statistical analysis
Y Chromosome - genetics
Y chromosomes
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Summary:We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplogroup frequencies were compared between 3 microdeletion classes and the non-deleted infertile males. Deletions arise on many different haplotypic backgrounds. No statistically significant differences in frequency were seen, although the small number of AZFa deletions lay predominantly on one branch of the Y haplotype tree.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03343792